CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18925
Family Name Poly [ADP-ribose] polymerase 1 inhibitor 3-[[4-fluoro-3-[4-(2-prop-2-enylpyrrolidine-2-carbonyl)piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one family
No. of Seeds 15 No. of Other Members 0
Family Centroid CFAMM00449777 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 and Cellular tumor antigen p53 Binder Superfamily
Class Class 3150

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Poly [ADP-ribose] polymerase 1 Inhibitor KU-0059436 Family 21 45
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 7 9
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Histamine H3 receptor ligand 2-methyl-6-[4-[(2S)-2-(pyrrolidin... 1 1
Histamine H3 receptor ligand 2-methyl-6-[4-[2-[(2R)-2-methylpy... 2 4
Poly [ADP-ribose] polymerase 1 inhibitor 2-fluoro-N-[2-(4-meth... 11 0
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-phe... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor Acylpiperazine analog... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449785 CHEMBL597541 Bioactive 3-[[3-(2,8-diazaspiro[4.5]decane-8-carbonyl)-4-fluorophenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449778 CHEMBL591589 Bioactive 3-[[4-fluoro-3-[4-[(2R)-2-methylazetidine-2-carbonyl]piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449784 CHEMBL596702 Bioactive 3-[[4-fluoro-3-[4-(1-pyrrolidin-1-ylcyclopentanecarbonyl)piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449777 CHEMBL590632 Bioactive 3-[[4-fluoro-3-[4-(2-prop-2-enylpyrrolidine-2-carbonyl)piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449783 CHEMBL605760 Bioactive 3-[[4-fluoro-3-[4-[(2R)-pyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449776 CHEMBL605552 Bioactive SureCN4251613
CFAMM00449782 CHEMBL599167 Bioactive 3-[[4-fluoro-3-[4-[(2S)-pyrrolidine-2-carbonyl]piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449775 CHEMBL590548 Bioactive SureCN3910160
CFAMM00449781 CHEMBL603235 Bioactive 3-[[3-[4-[1-(ethylamino)cyclopentanecarbonyl]piperazine-1-carbonyl]-4-fluorophenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449774 CHEMBL597926 Bioactive SureCN4251620
CFAMM00449787 CHEMBL592230 Bioactive 3-[[3-[4-(2-ethylpyrrolidine-2-carbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449780 CHEMBL592486 Bioactive SureCN4241844
CFAMM00449786 CHEMBL597313 Bioactive 3-[[4-fluoro-3-[4-[1-(methylamino)cyclopentanecarbonyl]piperazine-1-carbonyl]phenyl]methyl]-4,5-dimethyl-1H-pyridazin-6-one
CFAMM00449773 CHEMBL597927 Bioactive SureCN4251624
CFAMM00449779 CHEMBL592487 Bioactive SureCN3910161

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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