CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18930
Family Name Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N-methylethanesulfonamide family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00449812 Functional Category Bioactive
Superfamily Beta-lactamase and Histamine H4 receptor Binder Superfamily
Class Class 343

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449815 CHEMBL591500 Bioactive 2-[[6-chloro-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N,N-diethylethanesulfonamide
CFAMM00449812 CHEMBL591011 Bioactive 2-[[6-chloro-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N-methylethanesulfonamide
CFAMM00449818 CHEMBL592379 Bioactive 2-[[6-chloro-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N-phenylethanesulfonamide
CFAMM00449811 CHEMBL591250 Bioactive 6-chloro-2-(4-methylpiperazin-1-yl)-N-(2-morpholin-4-ylsulfonylethyl)quinazolin-4-amine
CFAMM00449817 CHEMBL592663 Bioactive 2-[[6-chloro-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N-methyl-N-phenylethanesulfonamide
CFAMM00449816 CHEMBL591249 Bioactive 6-chloro-2-(4-methylpiperazin-1-yl)-N-[2-(2-methylpiperidin-1-yl)sulfonylethyl]quinazolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27396 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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