CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18932
Family Name Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00449824 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Cellular tumor antigen p53 Binder Superfamily
Class Class 999

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
MK-6096 family 3 69
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Mitogen-activated protein kinase 14 Inhibitor Ro-3201195 Family 1 2
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor N-(2... 1 4
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 3 15
Vascular endothelial growth factor receptor 2 and Vascular end... 1 9
Vascular endothelial growth factor receptor 2 and Vascular end... 8 1
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 5
Vascular endothelial growth factor receptor 2 and Vascular end... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449821 CHEMBL596078 Bioactive AGN-PC-07R60O
CFAMM00449826 CHEMBL591091 Bioactive AGN-PC-07R5ZA
CFAMM00449825 CHEMBL606459 Bioactive AGN-PC-07R5WW
CFAMM00449824 CHEMBL600873 Bioactive AGN-PC-07R5ZB

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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