CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1896
Family Name Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-088X33 family
No. of Seeds 15 No. of Other Members 5
Family Centroid CFAMM00328640 Functional Category Bioactive
Superfamily Oxytocin receptor and Histamine H3 receptor Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Histamine H3 receptor ligand SureCN1857507 family 1 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Histamine H3 receptor ligand (4-propan-2-yl-1,4-diazepan-1-yl)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00328641 CHEMBL1222651 Bioactive SureCN8229206
CFAMM00328649 CHEMBL1222718 Bioactive SureCN8229131
CFAMM00328640 CHEMBL1222650 Bioactive AGN-PC-088X33
CFAMM00328648 CHEMBL1222719 Bioactive SureCN8229181
CFAMM00328639 CHEMBL1222799 Bioactive SureCN8231751
CFAMM00328647 CHEMBL1222863 Bioactive SureCN8229707
CFAMM00328646 CHEMBL1222864 Bioactive AGN-PC-080AET
CFAMM00328645 CHEMBL1222865 Bioactive SureCN8229223
CFAMM00328651 CHEMBL1222717 Bioactive SureCN8229201
CFAMM00328642 CHEMBL1222649 Bioactive SureCN8231211
CFAMM00328650 CHEMBL1222800 Bioactive SureCN8231203

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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