CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19032
Family Name Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta ligand 3-[3-(3-methylsulfonylphenoxy)phenyl]-2-propan-2-yl-8-(trifluoromethyl)imidazo[1,2-a]pyridine family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00450221 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 Inhibitor Cimicoxib Superfamily
Class Class 1249

Cousin Family NamesSeedsMembers
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 11 35
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 2 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Phosphatidylinositol 4-kinase beta inhibitor (4E)-2-fluoro-4-[... 1 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Cannabinoid receptor 2 ligand 6-chloro-1-(cyclohexylmethyl)-2-... 4 3
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Glucagon receptor ligand SureCN2647807 family 3 7
Prostaglandin G/H synthase 2 inhibitor SureCN6777506 family 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 13 8
Beta-secretase 1 and Amyloid beta A4 protein inhibitor SureCN3... 1 5
Neuropeptide S receptor ligand 5-(4-chlorophenyl)-6-methoxy-5-... 4 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Angiopoietin-1 receptor ligand 4-[4-(6-methoxynaphthalen-2-yl)... 6 4
Transitional endoplasmic reticulum ATPase inhibitor 4-[4-[(5-c... 4 10
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Prostaglandin G/H synthase 2 inhibitor 2-(3,5-dibromo-4-methox... 2 0
Glucokinase inhibitor AGN-PC-03ZE4O family 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00450382 CHEMBL612007 Bioactive 3-[[3-[3-(3-methylsulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1,3-thiazolidine
CFAMM00450381 CHEMBL611467 Bioactive 2-tert-butyl-3-[3-(3-methylsulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine
CFAMM00450383 CHEMBL611735 Bioactive 2-benzyl-3-[3-(3-methylsulfonylphenoxy)phenyl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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