CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM191
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 1A ligand SureCN7544532 family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00168791 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor Ligand AEW-541 Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
MK-6096 family 3 69
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00308750 CHEMBL2152283 Bioactive 3-(2-morpholin-4-ylethoxy)-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)aniline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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