CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1922
Family Name Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl]furan-2-yl]phenyl]methyl]-2-(trifluoromethyl)pyrimidine-4-carboxamide family
No. of Seeds 6 No. of Other Members 9
Family Centroid CFAMM00328858 Functional Category Bioactive
Superfamily Cathepsin K and Neuronal acetylcholine receptor subunit alpha-4 Binder Superfamily
Class Class 918

Cousin Family NamesSeedsMembers
Cathepsin K Inhibitor Relacatib Family 26 32
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Smoothened homolog Inhibitor LDE225 Family 3 76
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Gonadotropin-releasing hormone receptor ligand AGN-PC-034WF4 f... 8 23
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Collagenase 3 and 72 kDa type IV collagenase inhibitor SureCN3... 1 0
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[4-(4-pip... 1 11
Gonadotropin-releasing hormone receptor and Voltage-dependent ... 2 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
MAP kinase-activated protein kinase 2 inhibitor 4-[4-oxo-8-pip... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-073HN6 f... 1 1
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Collagenase 3 inhibitor SureCN1316041 family 4 3
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Motilin receptor ligand SureCN13392247 family 1 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00328856 CHEMBL1223284 Bioactive N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl]furan-2-yl]phenyl]methyl]pyrimidine-4-carboxamide
CFAMM00328860 CHEMBL1223562 Bioactive SureCN1316346
CFAMM00328853 CHEMBL1223492 Bioactive N-[[3-[5-[[(2S)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]furan-2-yl]phenyl]methyl]-2-(trifluoromethyl)pyrimidine-4-carboxamide
CFAMM00328859 CHEMBL1223563 Bioactive SureCN1316657
CFAMM00328858 CHEMBL1223421 Bioactive N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl]furan-2-yl]phenyl]methyl]-2-(trifluoromethyl)pyrimidine-4-carboxamide
CFAMM00328857 CHEMBL1223420 Bioactive 2-chloro-N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl]furan-2-yl]phenyl]methyl]pyrimidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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