CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19256
Family Name Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquinazolin-6-yl)-2-naphthalen-2-ylacetamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00451192 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 7
Class Class 824

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-... 5 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Plasmepsin-2 and Cathepsin D inhibitor N'-(3,4-dimethylacridin... 1 0
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00451191 CHEMBL7176 Bioactive N-(2,4-diamino-5-chloroquinazolin-6-yl)-2-naphthalen-2-ylacetamide
CFAMM00451192 CHEMBL7049 Bioactive N-(2,4-diamino-5-methylquinazolin-6-yl)-2-naphthalen-2-ylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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