CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19303
Family Name Interstitial collagenase and 72 kDa type IV collagenase inhibitor (2R,3S)-N-[(2R)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-3-[(1,3-dioxoisoindol-2-yl)methyl]-N'-hydroxy-2-(2-methylpropyl)butanediamide family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00451382 Functional Category Bioactive
Superfamily Tumor necrosis factor Inhibitor Thalidomide Superfamily
Class Class 486

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-4-[(3S)-3-flu... 1 5
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 162
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrr... 2 2
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00451382 CHEMBL74670 Bioactive (2R,3S)-N-[(2R)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-3-[(1,3-dioxoisoindol-2-yl)methyl]-N'-hydroxy-2-(2-methylpropyl)butanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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