CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19364
Family Name Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit beta-2 ligand 5-[[(2S)-azetidin-2-yl]methoxy]-3-(6-bromopyridin-3-yl)-2-chloropyridine family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00451581 Functional Category Bioactive
Superfamily Neuronal acetylcholine receptor subunit alpha-4 Ligand Ispronicline Superfamily
Class Class 796

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 1 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
B2 bradykinin receptor ligand SureCN13145573 family 7 6
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00451581 CHEMBL86051 Bioactive 5-[[(2S)-azetidin-2-yl]methoxy]-3-(6-bromopyridin-3-yl)-2-chloropyridine
CFAMM00451586 CHEMBL83738 Bioactive 5-[[(2S)-azetidin-2-yl]methoxy]-3-[(E)-2-(5-bromo-6-fluoropyridin-3-yl)ethenyl]-2-chloropyridine
CFAMM00451585 CHEMBL84154 Bioactive 3-(6-bromopyridin-3-yl)-2-chloro-5-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
CFAMM00451584 CHEMBL79702 Bioactive 5-[[(2S)-azetidin-2-yl]methoxy]-2-bromo-3-pyridin-3-ylpyridine
CFAMM00451583 CHEMBL79515 Bioactive 3-[(E)-2-(2-bromopyridin-4-yl)ethenyl]-2-chloro-5-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
CFAMM00451582 CHEMBL86050 Bioactive 5-[[(2S)-azetidin-2-yl]methoxy]-3-(5-bromo-6-fluoropyridin-3-yl)-2-chloropyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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