CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19468
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase and Dihydrofolate reductase inhibitor PY856 family
No. of Seeds 1 No. of Other Members 3
Family Centroid CFAMM00451960 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Dihydrofolate reductase Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00451960 CHEMBL88430 Bioactive PY856

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26413 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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