CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19540
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand (3E)-3-(7-methoxyimidazo[4,5-c]quinolin-2-ylidene)-1,2-oxazole family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00452179 Functional Category Bioactive
Superfamily GABA theta subunit and Histamine H3 receptor Binder Superfamily
Class Class 1877

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 10 23
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 1
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00452182 CHEMBL95623 Bioactive (3E)-3-(8-methoxyimidazo[4,5-c]quinolin-2-ylidene)-1,2-oxazole
CFAMM00452179 CHEMBL94698 Bioactive (3E)-3-(7-methoxyimidazo[4,5-c]quinolin-2-ylidene)-1,2-oxazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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