CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1959
Family Name Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00329117 Functional Category Bioactive
Superfamily Histamine H1 receptor Ligand Mizolastine Superfamily
Class Class 667

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
BIBT986 family 7 96
IPI-145 family 2 4
SB989 family 17 91
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Tryptase Inhibitor Babim Family 12 90
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor CI-9... 3 13
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Renin inhibitor AGN-PC-073MLF family 7 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Fatty acid-binding protein, adipocyte inhibitor AGN-PC-02W5KO ... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 5
Substance-K receptor ligand SureCN9035669 family 10 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077DC5 family 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00329117 CHEMBL1224152 Bioactive AGN-PC-088XRP
CFAMM00329123 CHEMBL1224388 Bioactive AGN-PC-088XVU

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45870 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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