CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19624
Family Name Fibroblast growth factor receptor 1 and Proto-oncogene tyrosine-protein kinase Src ligand 1,6-naphthyridin-2(1H)-one deriv. 8h family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00452460 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Estrogen receptor Binder Superfamily
Class Class 3526

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Hepatocyte growth factor receptor ligand [3,5-dichloro-4-[4-(3... 1 1
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Beta-secretase 1 and Amyloid beta A4 protein inhibitor SureCN3... 1 5
Estrogen receptor beta and Estrogen receptor ligand SureCN6343... 2 1


External ID

Functional Category

Molecule Name

CFAMM00452459 CHEMBL419914 Bioactive 1,6-naphthyridin-2(1H)-one deriv. 8r
CFAMM00452460 CHEMBL104304 Bioactive 1,6-naphthyridin-2(1H)-one deriv. 8h

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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