CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1977
Family Name Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[1-(4-butoxyphenyl)ethenyl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00329214 Functional Category Bioactive
Superfamily Neprilysin Inhibitor Candoxatril Superfamily
Class Class 579

Cousin Family NamesSeedsMembers
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Renin Inhibitor Aliskiren Family 28 107
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Metabotropic glutamate receptor 2 Ligand LY341495 Family 4 14
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Pol polyprotein inhibitor 180968-31-4 family 8 13
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Neprilysin inhibitor SureCN389939 family 5 6
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Angiotensin-converting enzyme inhibitor (2S,4S)-1-[(2S)-2-meth... 1 0
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-07... 2 6
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00329213 CHEMBL332114 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-[4-(2-phenylethoxy)phenyl]ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00329204 CHEMBL332168 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(3-methoxyphenyl)ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00329216 CHEMBL333015 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(4-methoxyphenyl)ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00329214 CHEMBL122507 Bioactive (2S,3S,4S)-4-[1-(4-butoxyphenyl)ethenyl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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