CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM19804
Family Name Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11 inhibitor SureCN5257393 family
No. of Seeds 6 No. of Other Members 4
Family Centroid CFAMM00453168 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 11 and Mitogen-activated protein kinase 14 Binder Superfamily 4
Class Class 1532

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
D(2) dopamine receptor Ligand Sertindole Family 3 173
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
ABC294640 family 5 75
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Nociceptin receptor ligand SureCN3543370 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 3 3
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
NADPH oxidase 4 and NADPH oxidase 1 inhibitor 2-(2-chloropheny... 2 5
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00453168 CHEMBL1091921 Bioactive SureCN5257393
CFAMM00453167 CHEMBL1091923 Bioactive SureCN5258138
CFAMM00453166 CHEMBL1089197 Bioactive SureCN5257910
CFAMM00453171 CHEMBL1092246 Bioactive SureCN14411787
CFAMM00453170 CHEMBL1093456 Bioactive 2-[4-[3-(4-chlorophenyl)-4-pyridin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]ethanol
CFAMM00453169 CHEMBL1089520 Bioactive 4-[3-(4-chlorophenyl)-4-pyridin-4-yl-1H-pyrazol-5-yl]piperidine-1-sulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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