CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20015
Family Name Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]amino]pyridine-3-sulfonamide family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00454128 Functional Category Bioactive
Superfamily Prothrombin and Pol polyprotein Binder Superfamily 2
Class Class 85

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Chymase Inhibitor NK3201 Family 1 0
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Beta-secretase 1 inhibitor 1-N-[(1S,2S)-3-(3,5-difluorophenyl)... 2 16
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
Collagenase 3 and Interstitial collagenase inhibitor (2R,5R)-N... 4 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(butyl... 2 4
Pol polyprotein inhibitor 169168-47-2 family 4 0
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 1 0
Prothrombin inhibitor N-[(1S)-2-[4-(2-fluoroethyl)piperidin-1-... 5 0
Calpain-1 catalytic subunit inhibitor N-[(2S)-3,4-dioxo-1-phen... 1 0
Prothrombin inhibitor 2-[(3S)-4-[4-(2-fluoroethyl)piperidin-1-... 1 0
Pol polyprotein inhibitor AC1LASR0 family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00454128 CHEMBL121423 Bioactive N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]amino]pyridine-3-sulfonamide
CFAMM00454127 CHEMBL163817 Bioactive N-[(2S)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]-4-[[(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]amino]pyridine-3-sulfonamide
CFAMM00454120 CHEMBL118428 Bioactive N-[(2S)-1-[4-(2-fluoroethyl)piperidin-1-yl]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-4-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide
CFAMM00454126 CHEMBL331871 Bioactive N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]pyridine-3-sulfonamide
CFAMM00454125 CHEMBL274142 Bioactive N-[(1S)-2-[4-(2-fluoroethyl)piperidin-1-yl]-1-(4-methoxyphenyl)-2-oxoethyl]-4-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamide
CFAMM00454124 CHEMBL162174 Bioactive N-[(2S)-3-(4-aminophenyl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-4-[[(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]amino]pyridine-3-sulfonamide
CFAMM00454129 CHEMBL332293 Bioactive N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-4-[[(2S)-1-(3,4-dimethoxyphenyl)-3-hydroxypropan-2-yl]amino]pyridine-3-sulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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