CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20042
Family Name Retinoic acid receptor RXR-gamma and Retinoic acid receptor RXR-beta ligand (4-ethoxycarbonylphenyl) 1,4,4-trimethyl-2,3-dihydroquinoline-6-carboxylate family
No. of Seeds 3 No. of Other Members 36
Family Centroid CFAMM00454291 Functional Category Bioactive with Natural Product
Superfamily Acetylcholinesterase and Cellular tumor antigen p53 Binder Superfamily
Class Class 761

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Androgen receptor ligand trifluoromethyl 10-methoxy-4-methyl-2... 2 57
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
DNA-dependent protein kinase catalytic subunit inhibitor 5-hyd... 1 7
2-[4-(dimethylamino)benzylidene]-6-methoxybenzo[de]chromen-3(2... 1 0


External ID

Functional Category

Molecule Name

CFAMM00454293 CHEMBL120210 Bioactive (4-ethoxycarbonylphenyl) 4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinoline-6-carboxylate
CFAMM00454291 CHEMBL422607 Bioactive (4-ethoxycarbonylphenyl) 1,4,4-trimethyl-2,3-dihydroquinoline-6-carboxylate
CFAMM00454316 CHEMBL331642 Bioactive (4-ethoxycarbonylphenyl) 1,4,4,7-tetramethyl-2,3-dihydroquinoline-6-carboxylate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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