CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20045
Family Name Potassium-transporting ATPase alpha chain 1 and Potassium-transporting ATPase subunit beta inhibitor 4-[4-(3-imidazol-1-ylpropoxy)phenyl]-2-phenyl-1,3-thiazole;hydrate;hydrochloride family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00454339 Functional Category Bioactive
Superfamily Cytochrome P450 2D6 and Aromatase Binder Superfamily
Class Class 1249

Cousin Family NamesSeedsMembers
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Leukotriene A-4 hydrolase Inhibitor 2-(4-piperidin-1-ylmethylp... 5 47
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 5 subunit alpha Ligand Lubeluzole ... 3 12
Rho-associated protein kinase 2 inhibitor SureCN13457044 family 1 17
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 14 2
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Inositol monophosphatase 1 and Microtubule-associated protein ... 1 12
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Sodium channel protein type 5 subunit alpha and Sodium channel... 15 8
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 1 0
Cysteinyl leukotriene receptor 1 and Platelet-activating facto... 1 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 2 0
Nuclear receptor ROR-gamma and Neuropeptide S receptor ligand ... 1 0
Histamine H3 receptor ligand [4-[2-[2-(1H-imidazol-5-yl)ethyls... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00454330 CHEMBL332028 Bioactive 6-(7-tert-butyl-3,3-dimethyl-2H-1-benzofuran-5-yl)imidazo[2,1-b][1,3]thiazole
CFAMM00454339 CHEMBL1202672 Bioactive 4-[4-(3-imidazol-1-ylpropoxy)phenyl]-2-phenyl-1,3-thiazole;hydrate;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26179 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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