CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2008
Family Name 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inhibitor (3r,4s)-1-[(4-Amino-5h-Pyrrolo[3,2-D]pyrimidin-7-Yl)methyl]-4-[(Butylsulfanyl)methyl]pyrrolidin-3-Ol family
No. of Seeds 7 No. of Other Members 6
Family Centroid CFAMM00322549 Functional Category Bioactive
Superfamily S-methyl-5'-thioadenosine phosphorylase and 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Binder Superfamily
Class Class 3353

Cousin Family NamesSeedsMembers
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Adenosine receptor A3 Ligand CF101 Family 24 560
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Equilibrative nucleoside/nucleobase transporter Inhibitor Nitr... 23 98
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 17 17
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
S-methyl-5'-thioadenosine phosphorylase inhibitor 1-[(4-amino-... 7 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 8 10
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A3 ligand (2R,3R,4S)-2-[6-[(3-bromophenyl)m... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Mitogen-activated protein kinase 14 inhibitor SureCN828349 family 1 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00329475 CHEMBL191436 Bioactive DADMe-ImmA-Bn
CFAMM00329473 CHEMBL1242854 Bioactive (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(ethylsulfanylmethyl)pyrrolidin-3-ol
CFAMM00329478 CHEMBL1230265 Bioactive (3r,4s)-1-[(4-Amino-5h-Pyrrolo[3,2-D]pyrimidin-7-Yl)methyl]-4-{[(4-Chlorophenyl)sulfanyl]methyl}pyrrolidin-3-Ol
CFAMM00329471 CHEMBL1232180 Bioactive (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(benzylsulfanyl)methyl]pyrrolidin-3-ol
CFAMM00329477 CHEMBL188375 Bioactive AGN-PC-075IBQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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