CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20125
Family Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-6-methoxy-2-propan-2-ylquinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00454635 Functional Category Bioactive
Superfamily Proteinase-activated receptor 1 and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 2321

Cousin Family NamesSeedsMembers
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Fluv... 6 53
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Stat... 5 21
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 2 6
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor Sure... 1 1
Proteinase-activated receptor 1 ligand 2-[2-[(E)-2-[(3R,3aS,4S... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00454635 CHEMBL122112 Bioactive (4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-6-methoxy-2-propan-2-ylquinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
CFAMM00454634 CHEMBL332057 Bioactive (4S,6S)-6-[2-[5-(4-fluorophenyl)-1-(4-methoxyphenyl)-3-propan-2-ylpyrazol-4-yl]ethyl]-4-hydroxyoxan-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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