CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20136
Family Name Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-[2-[2-(dimethylamino)ethoxy]quinolin-5-yl]ethylamino]-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00454664 Functional Category Bioactive
Superfamily Sodium channel protein type 5 subunit alpha Ligand Dibucaine Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
NS3 and Non-structural protein 4A inhibitor 4-[2-[[(2S)-2-[[(2... 2 0


External ID

Functional Category

Molecule Name

CFAMM00454665 CHEMBL376817 Bioactive methyl (2S)-2-[[(2S)-2-[[(2S)-2-[4-[2-[4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-4-amino-1-methoxy-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutoxy]quinolin-7-yl]oxybutanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoate
CFAMM00454664 CHEMBL1221746 Bioactive (3S)-3-[[(2S)-4-[2-[2-[2-(dimethylamino)ethoxy]quinolin-5-yl]ethylamino]-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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