CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20146
Family Name 5-hydroxytryptamine receptor 2A and Histamine H1 receptor ligand 3-[4-(2-chloro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid family
No. of Seeds 6 No. of Other Members 2
Family Centroid CFAMM00454696 Functional Category Bioactive
Superfamily Histamine H1 receptor and Alpha-1B adrenergic receptor Binder Superfamily 2
Class Class 1237

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Histamine H1 receptor Ligand Alcaftadine Family 1 4
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 6
Delta-type opioid receptor and Kappa-type opioid receptor liga... 10 4
Histamine H1 receptor ligand 3-[4-(10H-imidazo[1,2-b][2]benzaz... 2 0
Glutamate receptor 1 and Glutamate receptor 2 ligand AGN-PC-07... 1 1
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0


External ID

Functional Category

Molecule Name

CFAMM00454698 CHEMBL1222693 Bioactive 3-[4-(1,2-dimethyl-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
CFAMM00454696 CHEMBL1222695 Bioactive 3-[4-(2-chloro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
CFAMM00454695 CHEMBL1222694 Bioactive 2,2-dimethyl-3-[4-(2-methyl-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]propanoic acid
CFAMM00454700 CHEMBL1222763 Bioactive 3-[4-(2-fluoro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
CFAMM00454693 CHEMBL1222623 Bioactive 3-[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)-1,4-diazepan-1-yl]-2,2-dimethylpropanoic acid
CFAMM00454699 CHEMBL1222762 Bioactive 3-[4-(1-chloro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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