CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2015
Family Name Heat shock protein HSP 90-alpha inhibitor 3-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]prop-2-yn-1-ol family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00329568 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 481

Cousin Family NamesSeedsMembers
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Glucagon receptor ligand SureCN2647807 family 3 7
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Sodium channel protein type 5 subunit alpha and Sodium channel... 15 8
Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00329566 CHEMBL1230584 Bioactive 5-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]-2-methylpent-4-yn-2-ol
CFAMM00329571 CHEMBL467399 Bioactive 848695-25-0
CFAMM00329564 CHEMBL2205800 Bioactive 3-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]propan-1-ol
CFAMM00329570 CHEMBL2205244 Bioactive 4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-5-phenylpyrrolo[2,3-d]pyrimidin-2-amine
CFAMM00329569 CHEMBL2205245 Bioactive 4-chloro-5-ethynyl-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-2-amine
CFAMM00329568 CHEMBL2205798 Bioactive 3-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]prop-2-yn-1-ol
CFAMM00329567 CHEMBL2205799 Bioactive 4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]but-3-yn-1-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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