CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2025
Family Name Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 family
No. of Seeds 7 No. of Other Members 29
Family Centroid CFAMM00329655 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
P2X purinoceptor 7 inhibitor SureCN110930 family 2 0
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Adenosine receptor A1 ligand SureCN1497799 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Neuropeptides B/W receptor type 1 ligand [4-(5-chloropyridin-2... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00329643 CHEMBL1288162 Bioactive 4-[[(3S)-azepan-3-yl]amino]-2-(4-chlorophenyl)thieno[3,2-c]pyridine-7-carboxamide
CFAMM00329682 CHEMBL1288221 Bioactive 2-(3-chloro-4-fluorophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00329655 CHEMBL1231626 Bioactive SureCN13010134
CFAMM00329654 CHEMBL1288191 Bioactive AGN-PC-09M7G9
CFAMM00329671 CHEMBL1287922 Bioactive 2-(4-chlorophenyl)-4-[[(3S)-piperidin-3-yl]amino]-[1,3]thiazolo[4,5-c]pyridine-7-carboxamide
CFAMM00329684 CHEMBL1288103 Bioactive 2-(4-chloro-3-fluorophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide
CFAMM00329676 CHEMBL1288303 Bioactive 2-(3-chlorophenyl)-4-[[(3S)-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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