| Cousin Family Names | Seeds | Members |
|---|
| Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... | 4 | 151 |
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 14 | 2769 |
| HIV protease Inhibitor Saquinavir Family | 64 | 428 |
| D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... | 22 | 170 |
| D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family | 5 | 74 |
| 5-hydroxytryptamine receptor 3A Ligand Granisetron Family | 26 | 212 |
| Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family | 9 | 243 |
| Sodium channel protein type 5 subunit alpha Ligand Disopyramid... | 4 | 352 |
| SUR2-type K(ATP) channel Ligand Nicorandil Family | 5 | 85 |
| Hepatocyte growth factor receptor Ligand Arq 197 Family | 10 | 400 |
| Glycogen synthase kinase-3 beta and Protein kinase C beta type... | 5 | 53 |
| Glycogen phosphorylase, muscle form Inhibitor PSN357 Family | 3 | 253 |
| Neuromedin-K receptor Ligand SB222200 Family | 17 | 235 |
| Cholecystokinin receptor type A Ligand Tarazepide Family | 6 | 323 |
| Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family | 13 | 179 |
| Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family | 5 | 154 |
| Glutamate receptor AMPA subtype Ligand CX-516 Family | 9 | 24 |
| Gamma-aminobutyric acid receptor Ligand E-2007 Family | 7 | 118 |
| Growth hormone receptor Ligand EP-51216 Family | 34 | 390 |
| Histone deacetylase 1 Inhibitor Panobinostat Family | 5 | 93 |
| D(3) dopamine receptor Ligand SB-277011 Family | 13 | 178 |
| Protein kinase C alpha type and Protein kinase C beta type Inh... | 16 | 86 |
| D(4) dopamine receptor Ligand SPI-376 Family | 7 | 84 |
| Substance-P receptor Ligand TAK-637 Family | 18 | 63 |
| Vascular endothelial growth factor receptor 1 and Angiopoietin... | 29 | 127 |
| TGF-beta receptor type-1 Ligand LY2157299 Family | 13 | 56 |
| C-C chemokine receptor type 3 Ligand YM-344031 Family | 19 | 106 |
| 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family | 7 | 44 |
| Lethal factor Inhibitor GM6001 Family | 50 | 435 |
| XL-888 family | 16 | 85 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... | 4 | 34 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... | 4 | 25 |
| NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family | 9 | 71 |
| Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family | 3 | 7 |
| Cannabinoid receptor 2 Ligand JWH-167 Family | 25 | 168 |
| Somatostatin receptor type 2 Ligand L-054852 Family | 13 | 88 |
| Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... | 12 | 70 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... | 2 | 8 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... | 9 | 40 |
| Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... | 4 | 21 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 4 | 93 |
| Alpha-1A adrenergic receptor Ligand L-771688 Family | 8 | 14 |
| Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... | 18 | 36 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... | 19 | 64 |
| Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... | 12 | 10 |
| Cholecystokinin receptor type A Ligand VL-0395 Family | 12 | 117 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... | 24 | 50 |
| Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... | 28 | 47 |
| Transient receptor potential cation channel subfamily V member... | 6 | 23 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... | 37 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... | 8 | 1 |
| D(4) dopamine receptor Ligand ABT-670 Family | 4 | 14 |
| Microsomal triglyceride transfer protein large subunit Inhibit... | 5 | 9 |
| Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... | 11 | 26 |
| Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... | 20 | 18 |
| C-C chemokine receptor type 5 Ligand GT-1282 Family | 21 | 14 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 4 | 6 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... | 8 | 4 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... | 4 | 10 |
| Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... | 6 | 14 |
| Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... | 19 | 32 |
| Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... | 11 | 46 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 3 | 29 |
| Glutamate receptor 1 Ligand Piriqualone Family | 8 | 67 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 3 | 27 |
| Endothelin B receptor Ligand IRL-2500 Family | 34 | 87 |
| Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... | 10 | 19 |
| Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... | 12 | 46 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 12 | 72 |
| Vasopressin V2 receptor Ligand YM-35278 Family | 33 | 38 |
| Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... | 2 | 3 |
| Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... | 12 | 160 |
| Histone deacetylase Inhibitor ST-5732 Family | 8 | 6 |
| Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... | 1 | 0 |
| Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... | 3 | 5 |
| 5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... | 8 | 12 |
| Cholecystokinin receptor type A ligand A-65186 family | 2 | 6 |
| Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... | 6 | 2 |
| Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... | 5 | 0 |
| Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... | 7 | 58 |
| Vascular endothelial growth factor receptor 2 and Receptor-typ... | 7 | 4 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 1 | 13 |
| Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... | 2 | 0 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 2 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 2 | 11 |
| Sodium-dependent serotonin transporter and Sodium-dependent do... | 10 | 2 |
| Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... | 4 | 6 |
| MAP kinase-activated protein kinase 2 and Mitogen-activated pr... | 5 | 2 |
| Histamine H3 receptor ligand AGN-PC-04YWRD family | 5 | 13 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 1 | 1 |
| Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... | 1 | 36 |
| Survival motor neuron protein and Nonstructural protein 1 inhi... | 1 | 18 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 3 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 4 | 0 |
| Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... | 1 | 7 |
| Mitogen-activated protein kinase 1 and Nonstructural protein 1... | 1 | 33 |
| Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... | 2 | 41 |
| Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... | 4 | 4 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 2 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 3 | 1 |
| Acetylcholinesterase inhibitor CHEMBL1651131 family | 6 | 9 |
| Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... | 2 | 0 |
| Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... | 5 | 1 |
| Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... | 3 | 1 |
| Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... | 4 | 6 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 3 | 2 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 18 | 3 |
| Substance-P receptor and Neuromedin-K receptor ligand SureCN88... | 4 | 14 |
| MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... | 14 | 0 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 1 | 0 |
| Renin and Potassium voltage-gated channel subfamily H member 2... | 9 | 2 |
| Mitogen-activated protein kinase 9 and MAP kinase-activated pr... | 1 | 0 |
| Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... | 2 | 1 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 2 | 3 |
| Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 2 | 1 |
| Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family | 2 | 4 |
| Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... | 7 | 0 |
| Rho-associated protein kinase 2 and Rho-associated protein kin... | 2 | 6 |
| MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... | 25 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... | 5 | 4 |
| Delta-type opioid receptor and Potassium voltage-gated channel... | 2 | 0 |
| Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... | 3 | 8 |
| Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... | 8 | 10 |
| Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 3 | 1 |
| Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... | 3 | 5 |
| Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... | 17 | 1 |
| Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... | 9 | 5 |
| High affinity nerve growth factor receptor and BDNF/NT-3 growt... | 4 | 3 |
| Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... | 6 | 4 |
| Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... | 2 | 1 |
| Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... | 2 | 0 |
| Vascular endothelial growth factor receptor 2 and Angiopoietin... | 14 | 0 |
| Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... | 6 | 8 |
| Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... | 3 | 2 |
| Dual specificity protein kinase CLK4 and Mitogen-activated pro... | 1 | 1 |
| RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... | 11 | 4 |
| Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... | 2 | 0 |
| Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... | 22 | 3 |
| Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... | 2 | 0 |
| Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... | 3 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... | 1 | 0 |
| Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... | 2 | 3 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 7 | 9 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 13 | 3 |
| Motilin receptor ligand SureCN2768052 family | 3 | 0 |
| Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... | 5 | 0 |
| Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... | 3 | 2 |
| Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... | 12 | 4 |
| Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... | 5 | 2 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... | 2 | 1 |
| Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... | 2 | 14 |
| Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... | 3 | 0 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... | 2 | 2 |
| Somatostatin receptor type 1 and Somatostatin receptor type 2 ... | 2 | 18 |
| Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... | 2 | 1 |
| Hepatocyte growth factor receptor and Protein-tyrosine kinase ... | 2 | 15 |
| Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... | 3 | 0 |
| CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... | 2 | 0 |
| Substance-P receptor ligand AGN-PC-004REJ family | 3 | 0 |
| Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... | 8 | 5 |
| Bombesin receptor subtype-3 ligand SureCN13887096 family | 3 | 1 |
| Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... | 17 | 13 |
| Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... | 11 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 2 | 2 |
| Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... | 2 | 1 |
| Cyclin-dependent kinase 2 inhibitor SureCN6589205 family | 2 | 2 |
| Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... | 3 | 1 |
| Substance-P receptor and Substance-K receptor ligand N-methyl-... | 2 | 2 |
| Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... | 2 | 1 |
| Angiopoietin-1 receptor and Vascular endothelial growth factor... | 1 | 0 |
| Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... | 2 | 0 |
| Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... | 2 | 0 |
| 72 kDa type IV collagenase and Interstitial collagenase inhibi... | 1 | 1 |
| Sodium-dependent serotonin transporter and D(2) dopamine recep... | 1 | 0 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 4 | 0 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 5 | 0 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 3 | 4 |
| MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801315 ... | 1 | 0 |
| Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... | 3 | 1 |
| Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... | 2 | 2 |
| Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... | 1 | 0 |
| Cyclin-dependent kinase 2 inhibitor pyrrollylactam indolinone ... | 1 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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