CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2052
Family Name E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide family
No. of Seeds 17 No. of Other Members 51
Family Centroid CFAMM00329963 Functional Category Bioactive with Natural Product
Superfamily Chymase and Mu-type opioid receptor Binder Superfamily
Class Class 3498

Cousin Family NamesSeedsMembers
Motilin receptor Ligand GSK962040 Family 30 457
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[... 18 26
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(2R,3R)-3-(4-c... 1 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Aldose reductase inhibitor Spiro-cimqat family 6 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00329965 CHEMBL575121 Bioactive SureCN2759826
CFAMM00329980 CHEMBL2398473 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxycyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329964 CHEMBL2381408 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329979 CHEMBL2398476 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[(1S,3S)-3-hydroxycyclopentyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329963 CHEMBL2398472 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329978 CHEMBL2398477 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-hydroxy-2-methylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329956 CHEMBL379173 Bioactive MI-63
CFAMM00330018 CHEMBL578238 Bioactive SureCN2624354
CFAMM00329962 CHEMBL578028 Bioactive SureCN2624333
CFAMM00329976 CHEMBL2398475 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[(1S,3R)-3-hydroxycyclopentyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00330010 CHEMBL2396674 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(3-hydroxy-3-methylcyclobutyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329961 CHEMBL575538 Bioactive SureCN2945583
CFAMM00329974 CHEMBL2398479 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[3-(methanesulfonamido)cyclobutyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329995 CHEMBL577393 Bioactive SureCN2759830
CFAMM00329960 CHEMBL1234332 Bioactive (2'R,3R,3'R,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00329959 CHEMBL2347375 Bioactive (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
CFAMM00330000 CHEMBL572933 Bioactive SureCN2624351

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26817 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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