CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20602
Family Name Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ligand 6'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene] family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00456396 Functional Category Bioactive
Superfamily Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ligand 6'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene] Superfamily
Class Class 966

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Kappa-type opioid receptor Ligand Dezocine Family 36 46
D(3) dopamine receptor Ligand U-99194A Family 7 33
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0


External ID

Functional Category

Molecule Name

CFAMM00456396 CHEMBL133579 Bioactive 6'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene]
CFAMM00456393 CHEMBL336332 Bioactive 8'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene]
CFAMM00456398 CHEMBL336970 Bioactive 7'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene]
CFAMM00456397 CHEMBL131417 Bioactive 5'-methoxyspiro[1,4-dihydroimidazole-5,3'-2,4-dihydro-1H-naphthalene]

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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