CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2066
Family Name Dihydrofolate reductase inhibitor (E)-3-[5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl]-1-[(1S)-1-propyl-1H-phthalazin-2-yl]prop-2-en-1-one family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00092957 Functional Category Bioactive
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 513

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330111 CHEMBL560502 Bioactive (E)-3-[5-[(2,4-diaminopyrimidin-5-yl)methyl]-3-hydroxy-2-methoxyphenyl]-1-(1-propyl-1H-phthalazin-2-yl)prop-2-en-1-one
CFAMM00330110 CHEMBL1673173 Bioactive (E)-3-[5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl]-1-[(1R)-1-(2-methoxypyrimidin-5-yl)-1H-phthalazin-2-yl]prop-2-en-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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