CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2071
Family Name Thymidylate synthase inhibitor AC1LAB82 family
No. of Seeds 17 No. of Other Members 0
Family Centroid CFAMM00330148 Functional Category Bioactive
Superfamily Thymidylate synthase Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6... 15 107
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Thymidylate synthase inhibitor AC1LABAB family 14 3
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 7 11
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Thymidylate synthase inhibitor SureCN6446340 family 2 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 1 0
Beta-secretase 1 inhibitor 3-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(... 1 0


External ID

Functional Category

Molecule Name

CFAMM00330153 CHEMBL340888 Bioactive AC1LAB8B
CFAMM00330161 CHEMBL340842 Bioactive AC1LAB8T
CFAMM00330146 CHEMBL127333 Bioactive (2S)-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-sulfamoylpentanoic acid
CFAMM00330154 CHEMBL341262 Bioactive AC1LAB98
CFAMM00330152 CHEMBL57269 Bioactive (2S)-5-[[(2R)-1-(benzenesulfonamido)-1-oxopropan-2-yl]amino]-2-[[4-[(2-methyl-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl)-prop-2-ynylamino]benzoyl]amino]-5-oxopentanoic acid
CFAMM00330160 CHEMBL355616 Bioactive SureCN6648714
CFAMM00330145 CHEMBL126242 Bioactive AC1LAB88
CFAMM00330151 CHEMBL127954 Bioactive (2S)-2-[[4-[(2,7-dimethyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-7-(methanesulfonamido)-7-oxoheptanoic acid
CFAMM00330159 CHEMBL168907 Bioactive TCMDC-137629
CFAMM00330150 CHEMBL126541 Bioactive AC1LAB8H
CFAMM00330158 CHEMBL127598 Bioactive AC1LAB95
CFAMM00330149 CHEMBL123614 Bioactive AC1LAB85
CFAMM00330157 CHEMBL127745 Bioactive AC1LAB8E
CFAMM00330148 CHEMBL127541 Bioactive AC1LAB82
CFAMM00330156 CHEMBL355662 Bioactive SureCN6449047
CFAMM00330147 CHEMBL355323 Bioactive TCMDC-138112
CFAMM00330155 CHEMBL167164 Bioactive SureCN6649605

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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