CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM20733
Family Name Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 subunit inhibitor N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-methylpyrimidine-5-carboxamide family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00456920 Functional Category Bioactive
Superfamily Nuclear factor NF-kappa-B p105 subunit and Transcription factor AP-1 Binder Superfamily
Class Class 4797

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Amine oxidase [flavin-containing] B and Metabotropic glutamate... 2 0


External ID

Functional Category

Molecule Name

CFAMM00456918 CHEMBL336546 Bioactive N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide
CFAMM00456920 CHEMBL132495 Bioactive N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-methylpyrimidine-5-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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