CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2078
Family Name Tyrosine-protein kinase ABL1 inhibitor 5-[(5-{[4-{[4-(2-Hydroxyethyl)piperazin-1-Yl]methyl}-3-(Trifluoromethyl)phenyl]carbamoyl}-2-Methylphenyl)ethynyl]-1-Methyl-1h-Imidazole-2-Carboxamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00330218 Functional Category Bioactive
Superfamily Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell growth factor receptor Kit Ligand Ponatinib Superfamily
Class Class 794

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
JAK Inhibitor Momelotinib Family 33 83
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04SU6B family 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330218 CHEMBL1236871 Bioactive 5-[(5-{[4-{[4-(2-Hydroxyethyl)piperazin-1-Yl]methyl}-3-(Trifluoromethyl)phenyl]carbamoyl}-2-Methylphenyl)ethynyl]-1-Methyl-1h-Imidazole-2-Carboxamide
CFAMM00330217 CHEMBL1784638 Bioactive AGN-PC-0A9UNV
CFAMM00330216 CHEMBL1784639 Bioactive AGN-PC-0A9RFZ
CFAMM00330214 CHEMBL1784637 Bioactive AGN-PC-07ZXHT

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26831 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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