CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2084
Family Name 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A ligand (Z)-but-2-enedioic acid;1-[2-[4-[(1R,3S)-6-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidine-2-thione family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00330254 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Binder Superfamily 4
Class Class 1324

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Zicronapine family 43 62
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2


External ID

Functional Category

Molecule Name

CFAMM00330259 CHEMBL1237332 Bioactive (Z)-but-2-enedioic acid;1-[2-[4-[6-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]-1,3-diazinane-2-thione
CFAMM00330258 CHEMBL1744112 Bioactive (Z)-but-2-enedioic acid;1-[2-[4-[5-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidine-2-thione
CFAMM00330257 CHEMBL1744111 Bioactive (Z)-but-2-enedioic acid;1-[2-[4-[5-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]-1,3-diazinane-2-thione
CFAMM00330255 CHEMBL1237321 Bioactive (Z)-but-2-enedioic acid;1-[2-[4-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidine-2-thione
CFAMM00330261 CHEMBL308157 Bioactive AGN-PC-000POD
CFAMM00330254 CHEMBL1237320 Bioactive (Z)-but-2-enedioic acid;1-[2-[4-[(1R,3S)-6-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidine-2-thione
CFAMM00330260 CHEMBL1237339 Bioactive 1-[3-[4-[6-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]propyl]imidazolidin-2-one;dihydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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