CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2086
Family Name 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A ligand 3-[2-[4-[6-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one;dihydrochloride family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00111593 Functional Category Bioactive
Superfamily Progesterone receptor and D(2) dopamine receptor Binder Superfamily 2
Class Class 667

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Progesterone receptor ligand AGN-PC-00B9AT family 4 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... 2 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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