CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2088
Family Name Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-2,3-dimethyl-4-oxoquinazolin-6-yl)methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide family
No. of Seeds 6 No. of Other Members 4
Family Centroid CFAMM00330277 Functional Category Bioactive
Superfamily Nicotinamide phosphoribosyltransferase and Beta-secretase 1 Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Transient receptor potential cation channel subfamily V member... 16 295
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[7-bromo-3... 1 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Glutamate receptor 1 and Glutamate receptor 2 ligand cp-465022... 1 6
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
P2X purinoceptor 7 inhibitor 2-chloro-N-[(1-hydroxy-3,3-dimeth... 1 8
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330270 CHEMBL1801864 Bioactive 4-[(7-chloro-3-methyl-4-oxo-1,2,3-benzotriazin-6-yl)methyl-(3-methylbut-2-enyl)amino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00330277 CHEMBL1801934 Bioactive 4-[(7-chloro-2,3-dimethyl-4-oxoquinazolin-6-yl)methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00330268 CHEMBL123756 Bioactive 289715-28-2
CFAMM00330275 CHEMBL1801567 Bioactive 4-[(7-chloro-3-methyl-4-oxoquinazolin-6-yl)methyl-(3-methylbut-2-enyl)amino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00330272 CHEMBL1801863 Bioactive 4-[[2-[[4-(3-aminopropyl)piperazin-1-yl]methyl]-7-chloro-3-methyl-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00330271 CHEMBL1801862 Bioactive 4-[[7-chloro-2-(hydroxymethyl)-3-methyl-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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