CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2097
Family Name Gastrin/cholecystokinin type B receptor and Cholecystokinin receptor type A ligand 2-[(3R,5R)-3-[(3-chlorophenyl)carbamoylamino]-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-1-yl]-N-(2-methylbutan-2-yl)acetamide family
No. of Seeds 15 No. of Other Members 12
Family Centroid CFAMM00189745 Functional Category Bioactive
Superfamily Cholecystokinin receptor type A and Gastrin/cholecystokinin type B receptor Binder Superfamily
Class Class 1656

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Fludi... 11 78
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Benzodiazepine receptor Ligand Clorazepate Family 2 3
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-[... 18 26
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Substance-K receptor and Neuromedin-K receptor ligand SureCN78... 2 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 4
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Oxytocin receptor ligand N-[1-[2-[[(2S)-1-amino-3-(3,4-dichlor... 1 0
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Calcitonin gene-related peptide type 1 receptor and Dual speci... 4 0
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Amyloid beta A4 protein inhibitor (2S,3R)-3-(2-methylpropyl)-N... 1 0
Aldose reductase inhibitor Spiro-cimqat family 6 8
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN9848375 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330376 CHEMBL127521 Bioactive 2-[(3R,5S)-5-benzyl-3-[(3-chlorophenyl)carbamoylamino]-8-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]-N-tert-butylacetamide
CFAMM00330381 CHEMBL126865 Bioactive N-tert-butyl-2-[(3R,5R)-3-[(3-chlorophenyl)carbamoylamino]-2-oxo-5-phenyl-4,5-dihydro-3H-1-benzazepin-1-yl]-N-methylacetamide
CFAMM00330387 CHEMBL320821 Bioactive N-(2-chlorophenyl)-2-[(3R,5S,7R)-5-(2-methylphenyl)-3-[(3-methylphenyl)carbamoylamino]-2-oxo-7-phenylazepan-1-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26855 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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