CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Platelet-activating factor receptor ligand A-85783 family
No. of Seeds 13 No. of Other Members 62
Family Centroid CFAMM00306045 Functional Category Bioactive
Superfamily Platelet-activating factor receptor Binder Superfamily
Class Class 1827

Cousin Family NamesSeedsMembers
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Thromboxane-A synthase inhibitor ethyl 5-[(Z)-[pyridin-3-yl-[3... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Histone deacetylase 4 and Histone deacetylase 3 inhibitor 4-az... 2 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand 5,6-dimethoxy-N,N-d... 2 3
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Platelet-activating factor receptor ligand (6-bromo-1H-indol-3... 2 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Platelet-activating factor receptor ligand benzyl 3-[(4R)-2-py... 1 0
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 2 0
Platelet-activating factor receptor ligand 2-[(Z)-[[1-(dimethy... 2 0
Arachidonate 5-lipoxygenase inhibitor 1-[1-(4-methylphenyl)sul... 1 0


External ID

Functional Category

Molecule Name

CFAMM00305996 CHEMBL100257 Bioactive N-[2-[6-(4-fluorophenyl)-3-[(3R)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carbonyl]indol-1-yl]ethyl]methanesulfonamide
CFAMM00306056 CHEMBL317090 Bioactive ABT-299
CFAMM00305985 CHEMBL433015 Bioactive N,N-dimethyl-6-pyridin-3-yl-3-[(3R)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carbonyl]indole-1-carboxamide
CFAMM00306054 CHEMBL98813 Bioactive SureCN8504914
CFAMM00305991 CHEMBL538366 Bioactive 6-(4-fluorophenyl)-N,N-dimethyl-3-[(3R)-2-oxo-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carbonyl]indole-1-carboxamide
CFAMM00306000 CHEMBL100251 Bioactive AGN-PC-02CC8N
CFAMM00306033 CHEMBL99583 Bioactive AGN-PC-074S5B
CFAMM00306045 CHEMBL98318 Bioactive A-85783
CFAMM00305988 CHEMBL99053 Bioactive SureCN8506520
CFAMM00306037 CHEMBL317745 Bioactive 6-(4-fluorophenyl)-N,N-dimethyl-3-[(3R)-3-(1-oxidopyridin-1-ium-3-yl)-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carbonyl]indole-1-carboxamide
CFAMM00306004 CHEMBL317735 Bioactive 2-[6-(4-fluorophenyl)-3-[(3R)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carbonyl]indol-1-yl]ethanesulfonamide
CFAMM00305987 CHEMBL98874 Bioactive AGN-PC-00OSAF
CFAMM00306036 CHEMBL98835 Bioactive SureCN8506638

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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