CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2103
Family Name S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN9974785 family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00330465 Functional Category Bioactive
Superfamily S-methyl-5'-thioadenosine phosphorylase and 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Binder Superfamily
Class Class 3353

Cousin Family NamesSeedsMembers
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Purine nucleoside phosphorylase inhibitor 7-[(3R,4S,5R)-3,4-di... 10 34
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 17 17
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
S-methyl-5'-thioadenosine phosphorylase inhibitor 1-[(4-amino-... 7 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330464 CHEMBL1241349 Bioactive SureCN9974804
CFAMM00330470 CHEMBL1241380 Bioactive SureCN9974778
CFAMM00330469 CHEMBL1241381 Bioactive SureCN9974781
CFAMM00330468 CHEMBL1243311 Bioactive SureCN9974780
CFAMM00330467 CHEMBL1240542 Bioactive SureCN9974782
CFAMM00330466 CHEMBL1243279 Bioactive SureCN9974766
CFAMM00330465 CHEMBL1243250 Bioactive SureCN9974785
CFAMM00330471 CHEMBL1243249 Bioactive SureCN9974764

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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