CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2115
Family Name Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protein kinase Src inhibitor AGN-PC-04TN25 family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00311639 Functional Category Bioactive
Superfamily AMP-activated protein kinase and Dihydroorotate dehydrogenase Binder Superfamily
Class Class 3008

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Ibrutinib family 2 27
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Dihydroorotate dehydrogenase Inhibitor Gnf-pf-85 Family 1 2
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 6
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A2a ligand AGN-PC-077RYF family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330583 CHEMBL1241678 Bioactive 5-[4-amino-1-[(3S)-oxolan-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-chlorophenol
CFAMM00330587 CHEMBL1241768 Bioactive 5-[4-amino-1-[(3R)-oxolan-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-chlorophenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27284 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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