CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2124
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor AGN-PC-09M1GA family
No. of Seeds 4 No. of Other Members 27
Family Centroid CFAMM00330681 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Histamine H1 receptor Ligand Mizolastine Family 14 603
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Reverse transcriptase Inhibitor Benzothiadiazines Family 4 21
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Plasminogen and Urokinase-type plasminogen activator Inhibitor... 3 26
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor PF-91... 8 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Type-2 angiotensin II receptor and Type-1A angiotensin II rece... 10 7
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M770 fa... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Type-1 angiotensin II receptor ligand AGN-PC-075NNL family 1 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... 2 13
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Phosphatidylinositol 3-kinase regulatory subunit alpha and Pho... 7 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 10
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Nuclear receptor subfamily 1 group I member 2 ligand AGN-PC-07... 2 13
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Carbonic anhydrase 2 and Carbonic anhydrase 9 inhibitor ZINC00... 1 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(4,5-dichlo... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Prothrombin inhibitor SureCN3000235 family 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330683 CHEMBL1765625 Bioactive AGN-PC-09M1GD
CFAMM00330682 CHEMBL1765621 Bioactive AGN-PC-09M1DW
CFAMM00330681 CHEMBL1765622 Bioactive AGN-PC-09M1GA

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27747 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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