CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2130
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ligand 1-[(4,4-diphenyl-1,3-dioxolan-2-yl)methyl]-4-(2-methoxyphenyl)piperazine family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00244037 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Superfamily
Class Class 1389

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Transient receptor potential cation channel subfamily V member... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[[4-(1... 4 18
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330712 CHEMBL2153423 Bioactive 1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2-methoxyphenyl)piperazine;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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