CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2131
Family Name Vascular endothelial growth factor receptor 2 and Mast/stem cell growth factor receptor Kit ligand Thienopyrimidine deriv. 11 family
No. of Seeds 10 No. of Other Members 27
Family Centroid CFAMM00330727 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 1151

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Aurora kinase A Inhibitor ABT-348 Family 20 49
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Epidermal growth factor receptor ligand 1-[4-[[(1S)-2-hydroxy-... 2 6
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Lutropin-choriogonadotropic hormone receptor and Follicle-stim... 1 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9PTC family 4 1
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9T4A family 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9T4C family 1 0
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 0
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Transient receptor potential cation channel subfamily V member... 1 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Transient receptor potential cation channel subfamily V member... 9 13
Transient receptor potential cation channel subfamily V member... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 0
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Aurora kinase A and Vascular endothelial growth factor recepto... 1 1
Epidermal growth factor receptor ligand AGN-PC-00RWKI family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00330757 CHEMBL1242373 Bioactive Thienopyrimidine deriv. 94
CFAMM00330736 CHEMBL371206 Bioactive Thienopyrimidine deriv. 26
CFAMM00330747 CHEMBL372744 Bioactive 1-[4-(4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
CFAMM00330727 CHEMBL371329 Bioactive Thienopyrimidine deriv. 11
CFAMM00330735 CHEMBL537435 Bioactive 1-[4-(4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea;hydrochloride
CFAMM00330721 CHEMBL370325 Bioactive Thienopyrimidine deriv. 24

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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