CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2186
Family Name Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand SureCN9022424 family
No. of Seeds 4 No. of Other Members 14
Family Centroid CFAMM00331134 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3-yl Acetate Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Indeglitazar family 3 39
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
DNA topoisomerase 2-beta Inhibitor 3-(6-(furan-2-yl)-4-phenylp... 1 3
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Phospholipase A2 inhibitor SureCN7046992 family 2 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Renin inhibitor SureCN1144364 family 3 15
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Renin inhibitor AGN-PC-09M9MJ family 2 23
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
NS5B protein inhibitor AC1O5AET family 3 1
Arachidonate 5-lipoxygenase-activating protein inhibitor SureC... 8 1
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
Arachidonate 5-lipoxygenase inhibitor AGN-PC-071TED family 9 12
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 6 5
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Glutamate receptor 2 and Glutamate receptor 4 ligand SureCN828... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 0
Bile acid receptor ligand SureCN1243717 family 1 4
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC40309500 Family 4 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00331125 CHEMBL340295 Bioactive SureCN9023435
CFAMM00331134 CHEMBL332813 Bioactive SureCN9022424
CFAMM00331122 CHEMBL125131 Bioactive 2-methyl-1-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-5-phenylmethoxyindole-3-carboxylic acid
CFAMM00331136 CHEMBL126053 Bioactive 2-[1-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-4-phenylmethoxyindol-3-yl]-2-phenylacetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26194 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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