CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM219
Family Name Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-propan-2-ylphenyl)-N-butyl-N-ethyl-5-methyltriazolo[4,5-b]pyridin-7-amine family
No. of Seeds 13 No. of Other Members 34
Family Centroid CFAMM00309035 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 and Beta-lactamase Binder Superfamily
Class Class 3062

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 9 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Corticotropin-releasing factor receptor 1 ligand 4-N-(2-bromo-... 9 48
Corticotropin-releasing factor receptor 1 ligand N-(2-bromo-4-... 5 0
Adenosine kinase inhibitor AGN-PC-074UAJ family 3 10
Adenosine kinase inhibitor abt-702 family 14 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-01ZUJC... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 5
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 7 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00GBP0... 3 1
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Corticotropin-releasing factor receptor 1 ligand N-butyl-N-eth... 2 1
Corticotropin-releasing factor receptor 1 ligand 3-(2,4-dibrom... 2 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 5 2
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Corticotropin-releasing factor receptor 1 ligand SureCN8181501... 4 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 7
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-008HTV... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00309023 CHEMBL169416 Bioactive SureCN8202273
CFAMM00309050 CHEMBL169561 Bioactive 3-(2-bromo-4-propan-2-ylphenyl)-N,N-bis(2-methoxyethyl)-5-methyltriazolo[4,5-b]pyridin-7-amine
CFAMM00309016 CHEMBL169781 Bioactive SureCN7626987
CFAMM00309021 CHEMBL355329 Bioactive 3-(2-bromo-4-propan-2-ylphenyl)-N-(cyclopropylmethyl)-N-(2-methoxyethyl)-5-methyltriazolo[4,5-d]pyrimidin-7-amine
CFAMM00309035 CHEMBL171202 Bioactive 3-(2-bromo-4-propan-2-ylphenyl)-N-butyl-N-ethyl-5-methyltriazolo[4,5-b]pyridin-7-amine
CFAMM00309048 CHEMBL424539 Bioactive 3-(2-bromo-4-propan-2-ylphenyl)-N-butyl-N-ethyl-5-methyltriazolo[4,5-d]pyrimidin-7-amine
CFAMM00309041 CHEMBL10504 Bioactive SureCN8044612
CFAMM00309027 CHEMBL168449 Bioactive N-benzyl-3-(2-bromo-4-propan-2-ylphenyl)-N-(2-methoxyethyl)-5-methyltriazolo[4,5-d]pyrimidin-7-amine
CFAMM00309040 CHEMBL166669 Bioactive SureCN7628570
CFAMM00309026 CHEMBL353732 Bioactive 3-(2-bromo-4-propan-2-ylphenyl)-N-(2-methoxyethyl)-5-methyl-N-prop-2-enyltriazolo[4,5-d]pyrimidin-7-amine
CFAMM00309052 CHEMBL295656 Bioactive AGN-PC-073OS9
CFAMM00309031 CHEMBL169952 Bioactive SureCN7484388
CFAMM00309058 CHEMBL169577 Bioactive SureCN7474752

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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