CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2194
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 1A ligand SureCN5761557 family
No. of Seeds 36 No. of Other Members 18
Family Centroid CFAMM00331209 Functional Category Bioactive
Superfamily Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 1A Binder Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Sodium-dependent serotonin transporter inhibitor 4-[(2S)-2-hyd... 4 0
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Sodium-dependent serotonin transporter inhibitor (2S)-1-[(2S,4... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Peroxisomal acyl-coenzyme A oxidase 1 inhibitor SureCN4859513 ... 1 10
Cytochrome P450 2D6 inhibitor AGN-PC-075CGG family 1 2
Beta-3 adrenergic receptor ligand SureCN7133396 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00331255 CHEMBL311964 Bioactive (2S)-1-(1H-indol-4-yloxy)-3-[(2S,4R)-2-methyl-4-(4-methyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331217 CHEMBL2112358 Bioactive (2S)-1-[(2S,4R)-4-(1-benzothiophen-6-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331235 CHEMBL338298 Bioactive SureCN5761018
CFAMM00331248 CHEMBL126184 Bioactive (2S)-1-(1H-indol-4-yloxy)-3-[(1R,5S)-3-(4-methoxy-1-benzothiophen-2-yl)-8-azabicyclo[3.2.1]octan-8-yl]propan-2-ol
CFAMM00331241 CHEMBL78405 Bioactive SureCN5793637
CFAMM00331254 CHEMBL80678 Bioactive (2S)-1-(1H-indol-4-yloxy)-3-[(2S,4R)-2-methyl-4-(6-methyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331209 CHEMBL129053 Bioactive SureCN5761557
CFAMM00331216 CHEMBL338632 Bioactive SureCN5758276
CFAMM00331221 CHEMBL125349 Bioactive SureCN5758155
CFAMM00331227 CHEMBL300340 Bioactive (2S)-1-[4-(4-methoxy-1-benzothiophen-2-yl)piperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331240 CHEMBL128866 Bioactive (2S)-1-[(2S,4R)-4-(4,6-dimethoxy-1-benzothiophen-2-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331220 CHEMBL2112357 Bioactive (2S)-1-[(2S,4R)-4-(1-benzothiophen-7-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331233 CHEMBL56156 Bioactive (2S)-1-(1H-indol-4-yloxy)-3-[4-(4-methyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331226 CHEMBL340374 Bioactive SureCN5760259
CFAMM00331239 CHEMBL57411 Bioactive (2S)-1-(1H-indol-4-yloxy)-3-[4-(6-methoxy-3-methyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331219 CHEMBL2112356 Bioactive SureCN5758436
CFAMM00331225 CHEMBL129605 Bioactive (2S)-1-[(2S,4R)-4-(4,6-dimethyl-1-benzothiophen-2-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331238 CHEMBL57494 Bioactive (2S)-1-(1H-indol-4-yloxy)-3-[4-(5-methoxy-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331251 CHEMBL129238 Bioactive (2S)-1-[(2S,4R)-4-(5-fluoro-1-benzothiophen-2-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331244 CHEMBL339086 Bioactive (2S)-1-[(2S,4R)-4-(6-methoxy-1-benzothiophen-2-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331257 CHEMBL310063 Bioactive (2S)-1-[(2S,4R)-4-(4,5-dimethoxy-1-benzothiophen-2-yl)-2-methylpiperidin-1-yl]-3-(1H-indol-4-yloxy)propan-2-ol
CFAMM00331224 CHEMBL313023 Bioactive (2R)-1-[(2S,4R)-4-(1-benzothiophen-4-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331237 CHEMBL340583 Bioactive (2S)-1-[(2-methyl-1H-indol-4-yl)oxy]-3-[(2S,4R)-2-methyl-4-(6-methyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331250 CHEMBL129233 Bioactive (2S)-1-[(1S,5R)-3-(4-methoxy-1-benzothiophen-2-yl)-8-azabicyclo[3.2.1]octan-8-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331211 CHEMBL55874 Bioactive 2-[1-[(2S)-2-hydroxy-3-(1H-indol-4-yloxy)propyl]piperidin-4-yl]-1-benzothiophen-6-ol
CFAMM00331230 CHEMBL131370 Bioactive (2S)-1-[(2-methyl-1H-indol-4-yl)oxy]-3-[(2S,4R)-2-methyl-4-(4-methyl-1-benzothiophen-2-yl)piperidin-1-yl]propan-2-ol
CFAMM00331243 CHEMBL129082 Bioactive (2S)-1-[(2S,4R)-4-(4-fluoro-1-benzothiophen-2-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331218 CHEMBL2112355 Bioactive (2S)-1-[(2-methyl-1H-indol-4-yl)oxy]-3-[(2S,4R)-2-methyl-4-(3-methyl-1-benzothiophen-6-yl)piperidin-1-yl]propan-2-ol
CFAMM00331236 CHEMBL293065 Bioactive (2S)-1-[4-(5-fluoro-1-benzothiophen-2-yl)piperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
CFAMM00331249 CHEMBL314163 Bioactive (2R)-1-[(2S,4R)-4-(1-benzothiophen-5-yl)-2-methylpiperidin-1-yl]-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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