CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2195
Family Name Estrogen receptor and Thymidylate synthase ligand (2R)-2-[[(4S)-4-carboxy-4-[[4-[[2-(hydroxymethyl)-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl]-prop-2-ynylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00331258 Functional Category Bioactive
Superfamily Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Superfamily
Class Class 617

Cousin Family NamesSeedsMembers
Thymidylate synthase Inhibitor Raltitrexed Family 1 15
Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Family 9 83
Thymidylate synthase Inhibitor Plevitrexed (r)-isomer Family 1 1
Dihydroorotase, putative Inhibitor 5-amino Orotate Family 2 4
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 1


External ID

Functional Category

Molecule Name

CFAMM00331258 CHEMBL1253498 Bioactive (2R)-2-[[(4S)-4-carboxy-4-[[4-[[2-(hydroxymethyl)-4-oxo-1,6,7,8-tetrahydrocyclopenta[g]quinazolin-6-yl]-prop-2-ynylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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