CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2205
Family Name Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3-fluorophenyl)-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea family
No. of Seeds 7 No. of Other Members 18
Family Centroid CFAMM00331357 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Hypoxia-inducible factor 1-alpha Binder Superfamily
Class Class 3520

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 13 6
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 2 3
Melanin-concentrating hormone receptor 1 ligand 3-(3-bromophen... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
Melanin-concentrating hormone receptor 1 ligand 1-[4-(3-cyanop... 4 9
Melanin-concentrating hormone receptor 1 ligand SureCN14265737... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN14101999... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Melanin-concentrating hormone receptor 1 ligand 1-[4-chloro-3-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00331364 CHEMBL229925 Bioactive 1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3,4-difluorophenyl)-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea
CFAMM00331357 CHEMBL1253878 Bioactive 1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3-fluorophenyl)-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea
CFAMM00331356 CHEMBL1254887 Bioactive 3-(3-chloro-4-fluorophenyl)-1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea
CFAMM00331349 CHEMBL229871 Bioactive 3-(3-chloro-4-fluorophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea
CFAMM00331362 CHEMBL389058 Bioactive 1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3-fluorophenyl)-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea
CFAMM00331354 CHEMBL229290 Bioactive 1-[(3R,6S)-6-[3-(aminomethyl)phenyl]-3-bicyclo[4.1.0]heptanyl]-3-(3-chloro-4-fluorophenyl)-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea
CFAMM00331366 CHEMBL1254973 Bioactive 1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3,4-difluorophenyl)-1-[(1-methylsulfonylpiperidin-4-yl)methyl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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