CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2212
Family Name Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-fluorophenyl)-1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[di(propan-2-yl)amino]ethyl]urea family
No. of Seeds 8 No. of Other Members 24
Family Centroid CFAMM00331428 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 Binder Superfamily 2
Class Class 3520

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 7 18
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 13 6
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 2 3
Melanin-concentrating hormone receptor 1 ligand 3-(3-bromophen... 4 0
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
Melanin-concentrating hormone receptor 1 ligand 1-[4-(3-cyanop... 4 9
Melanin-concentrating hormone receptor 1 ligand SureCN14265737... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Melanin-concentrating hormone receptor 1 ligand N-[2-[4-(3-cya... 3 9
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN14101999... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Melanin-concentrating hormone receptor 1 ligand 1-[4-chloro-3-... 1 1
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 3
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00331444 CHEMBL229767 Bioactive SureCN14266129
CFAMM00331450 CHEMBL1254327 Bioactive 3-(3-chlorophenyl)-1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00331436 CHEMBL229177 Bioactive 1-[(3R,6S)-6-[3-(aminomethyl)phenyl]-3-bicyclo[4.1.0]heptanyl]-3-(3-chloro-4-fluorophenyl)-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00331455 CHEMBL1254972 Bioactive 3-(3-chloro-4-fluorophenyl)-1-[2-[di(propan-2-yl)amino]ethyl]-1-[(6S)-6-[3-[(E)-methoxyiminomethyl]phenyl]-3-bicyclo[4.1.0]heptanyl]urea
CFAMM00331428 CHEMBL1254147 Bioactive 3-(3-chloro-4-fluorophenyl)-1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00331434 CHEMBL216820 Bioactive SureCN14102001
CFAMM00331446 CHEMBL434747 Bioactive 3-(3-chloro-4-fluorophenyl)-1-[2-[di(propan-2-yl)amino]ethyl]-1-[(3R,6S)-6-[3-[(E)-methoxyiminomethyl]phenyl]-3-bicyclo[4.1.0]heptanyl]urea
CFAMM00331426 CHEMBL229715 Bioactive SureCN14266061

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48705 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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