CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM22284
Family Name Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family
No. of Seeds 6 No. of Other Members 40
Family Centroid CFAMM00462775 Functional Category Bioactive with Human Metabolite & Natural Product
Superfamily Retinal dehydrogenase 1 and Arachidonate 15-lipoxygenase Binder Superfamily
Class Class 1012

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
DNA topoisomerase 2-beta Inhibitor Howiinol A (ghm-10) Family 1 42
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Inhibi... 2 119
Beta-lactamase Inhibitor 4-carboxyphenylboronic Acid Family 1 1
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 2,2-dimethoxy-1,2-diphenyl-... 1 16
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Calcium-activated potassium channel subunit alpha-1 Ligand Tri... 1 10
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
Solute carrier family 52, riboflavin transporter, member 2 Inh... 1 7
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 19
Protein kinase C delta type and Protein kinase C beta type inh... 3 9
Free fatty acid receptor 1 and Free fatty acid receptor 4 liga... 1 7
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4754... 2 17
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Free fatty acid receptor 1 ligand AGN-PC-0CCG7G family 1 2
Free fatty acid receptor 1 ligand 3-[4-[2-[3-(trifluoromethoxy... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Beta-lactamase inhibitor CHEMBL1358094 family 1 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Thromboxane A2 receptor ligand (Z)-7-[(4S,5R)-2,2-dimethyl-4-p... 2 9
Benzyloxycarbonyls Metabolite Benzyl acetate Family 5 53
Epoxides Metabolite Phenylmethylglycidic ester Family 2 17
Aromatic Homomonocyclic Compounds Metabolite Dimethylbenzyl ca... 2 11
Phenylpropenes Metabolite alpha-Amylcinnamyl acetate Family 3 3
Benzyloxycarbonyls Metabolite Benzyl acetoacetate Family 1 6
[(1S,2S,5R)-2-hydroxy-2-methyl-5-prop-1-en-2-ylcyclohexyl] ben... 1 2
4-hydroxy-2-(4-methoxycarbonylphenyl)-4-methyl-6-oxocyclohexan... 15 2
methylbenzoate NP 7-oxocyclohepta-1,3,5-trien-1-yl 3-methylben... 2 1
ethoxy-[6-[ethoxy(oxido)methylidene]-3,7-dioxo-1,5-dihydro-s-i... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00462750 CHEMBL357912 Bioactive 2-[4-(tridec-2-ynoxymethyl)phenyl]acetic acid
CFAMM00462734 CHEMBL144091 Bioactive SureCN9468509
CFAMM00462775 CHEMBL144207 Bioactive SureCN9469035
CFAMM00462768 CHEMBL2315251 Bioactive 3-[4-[2-[2-(methoxymethyl)phenyl]ethynyl]phenyl]propanoic acid
CFAMM00462774 CHEMBL144564 Bioactive SureCN9468442
CFAMM00462767 CHEMBL2315252 Bioactive 3-[4-[2-[3-(methoxymethyl)phenyl]ethynyl]phenyl]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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