CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2280
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor ligand SureCN4725780 family
No. of Seeds 49 No. of Other Members 8
Family Centroid CFAMM00282065 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Binder Superfamily 2
Class Class 1458

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand quinolone derivative Carteolol... 1 38
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1B Ligand Sb 224289 Family 2 8
Tubulin Inhibitor WR85915 Family 3 15
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Poly [ADP-ribose] polymerase 1 inhibitor 6-[1-(2,3-dihydro-1,4... 1 30
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
Trace amine-associated receptor 1 ligand EPPTB family 4 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Motilin receptor ligand SureCN14564469 family 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Sodium-dependent serotonin transporter and D(2) dopamine recep... 8 6
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 4 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Urotensin-2 receptor ligand SureCN2347581 family 10 10
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Mitogen-activated protein kinase 14 inhibitor ITX 5061 free ba... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-04UTCQ fa... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor KF 17828 family 4 11
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797384 f... 1 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN1600485 fa... 1 1
Urotensin-2 receptor ligand SureCN1472946 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00332167 CHEMBL1257262 Bioactive SureCN4729002
CFAMM00332166 CHEMBL1257261 Bioactive SureCN4729261
CFAMM00332172 CHEMBL1257614 Bioactive 6-[4-[4-(5,6,7,8-tetrahydronaphthalen-1-yl)piperazin-1-yl]butoxy]-2,3-dihydroisoindol-1-one
CFAMM00332171 CHEMBL1257613 Bioactive SureCN4727882

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24317 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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